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KMID : 1134820230520101005
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 10 p.1005 ~ p.1012
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Comparison of the Preadipocyte Differentiation Inhibitory Effects and Antioxidant Activities of Immature and Mature Yuzu Peel Hot Water Extracts In Vitro
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Lee Mi-Kyung
Yoon Ji-Young
Lee Hae-In
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Abstract
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Yuzu (Citrus junos) has various physiochemical properties and contains beneficial compounds that contribute to its health benefits. This study evaluated the anti-adipogenic and antioxidant effects of the hot-water extracts of mature yuzu peel (MYP) and immature yuzu peel (IYP). IYP contained higher levels of total polyphenols, flavonoids, naringin, and hesperidin than MYP, and had significantly greater 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging and ferric reducing antioxidant power activities. IYP and MYP down-regulated the expressions of adipogenic genes, such as CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ. They also down-regulated lipogenic genes, including fatty acid synthase and diacylglycerol O-acyltransferase 2 (DGAT2). These down-regulations inhibited adipocyte differentiation and reduced triglyceride contents, suggesting potential anti-obesity effects. Notably, IYP had a greater inhibitory effect on DGAT2 than MYP. Overall, these findings indicate that yuzu peel extracts, especially IYP extract, have potent antioxidant and anti-obesity properties.
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KEYWORD
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yuzu, immature yuzu peel, antioxidant, adipocytes differentiation, 3T3-L1
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